Differential effects of the serotonin receptors on cultured rat cerebral cortical neurons

Effects of serotonin (5-HT) on cerebral cortical neurons were examined by patch clamp techniques. 5-HT produced a variety of responses such as outward (19/73 patches/neurons), slow inward (15/73 patches/neurons), fast inward (8/73 patches/neurons), and mixed currents (initially fast inward deflection followed by an outward response: 2/73 patches/neurons), with a latency of 12 sec, 15 sec, 0 sec, and 0 sec respectively, at a holding potential of −60 mV in whole-cell patches. The fast inward currents were again evoked by a selective 5-HT3 receptor agonist, 1-(m-chlorophenyl)-biguanide hydrochloride (CPBG). In the cell-attached patch clamp configuration, 5-HT inside the patch pipette elicited single channel currents with slope conductances of 42 pS and 132 pS (4/42 patches/neurons). CPBG inside the patch pipette evoked inward single channel currents with a lower slope conductance of 41 pS (3/23 patches/neurons). In contrast, application of 5-HT or a 5-HT₂ receptor agonist, α-methyl-5-hydroxytryptamine-maleate, outside the patch pipette induced outward single channel currents with a major slope conductance of 140 pS (8/30 patches/neurons) or 135 pS (6/20 patches/neurons), respectively. These results indicate that the outward and fast inward currents may be mediated respectively by the 5-HT₂ receptor, which is coupled to a G-protein, and by the 5-HT₃ receptor, which contains the non-selective cation channel, and that the mixed type may be caused by both the 5-HT₂ and 5-HT₃ receptors. Received 27 September 1996; received after revision 4 November 1996; accepted 7 November 1996     

正常赖默—悌曼反应研究:超声波辐射与相转移催化合成方法

系统研究了正常及反常赖政－悌曼反应（NormalorAbnormalReliner－TiemannReavction，NRYorART）；研究了相转移住化方法和超声波辐射技术及其在正常Reliner—Tiemann（NRT）反应中的应用，从而使反应条件温和，效率增加，对邻比大，时间缩短，取得较好收效。     

全自动变频调速恒压供水系统的研制

采用交流电机变频调速技术，研制出全自动恒压供水系统，应用表明，该系统在节能，保持水质，水压平稳一及自动化等方面，大大优于传统供水方式，是供水行业的发展方向。     

一种指数型动态神经网络的定性分析

研究了由Ｔ．Ｄ．Ｃｈｉｕｃｈ和Ｒ．Ｍ．Ｇｏｏｄｍａｎ在１９８８年提出的指数型动态神经网络，给出了给定标准模式为该网络稳定点的一个简明的充分条件，并得到了这类稳定点的一步收敛半径。指出在概率意义下系统不存在伪稳态。     

一种二氢苯并噻喃衍生物的新型合成法

介绍２－丁烯醛与苯硫酚之间的酸催化分子间一步成环反应，合成一种二氢苯并噻喃衍生物的新方法，产品收率高达８４％。     

海滨锦葵（Kostelezkya virg inica）的引种生态学研究

海滨锦葵原产国美国东部沿海，是适宜海滨地区生长的多年生草木植物。在２５‰的盐水浇灌下，其种子产量达０．８－１．５ｔ／ｈａ；而去壳种子含３２％的蛋白质和２２％的脂肪，作为一种正待开发的耐盐作物在基本土引起了重视。     

用电容法测量原油凝点的可行性实验

介绍了基于原油介电常数随温度的变化与原油凝点之间存在的内在联系，测量原油凝点采用的电容法。叙述了非接触式电容传感器的测量原理和实验方法。实验结果表明，原油介电常数在原油的凝点附近达到一个峰值，这与实验室方法得到的结果相符，初步得出电容法测量原油凝点是可行的结论。为在线监测原油的流动性提供了一条实用化途径。     

大豆脂肪氧化酶催化油酸氧化反应动力学研究

用（NH4）2SO4三次盐析法从大豆中提取脂肪氧化酶；用测氧仪测定和跟踪脂肪氧化酶催化油酸氧化反应的反应过程。实验表明，脂肪氧化酶催化油酸氧化反应是按Michaelis机理进行。其最佳反应条件是：pH＝9．0；反应温度t＝30℃。反应活化能Ea＝74．95kJ·mol－1；米氏常数KM＝2．97×10－3mol·L－1。本文还测出了多种抑制剂对脂肪氧化酶的抑制效果。在应用方面提出了用抑制剂除去豆腥味的新方法。